| Designation | Mutation | Population | Main Clinical Effectsa |
|---|---|---|---|
| Sickle or S | African | Anemia, ischemic infarcts | |
| C | African | Mild anemia; interacts with HbS | |
| E | Southeast Asian | Microcytic anemia, splenomegaly, thalassemic phenotype | |
| Köln | Sporadic | Hemolytic anemia, Heinz bodies when splenectomized | |
| Yakima | Sporadic | Polycythemia | |
| Kansas | Sporadic | Mild anemia | |
| M. Iwata | Sporadic | Methemoglobinemia |
20110808
Table 99-3 Representative Abnormal Hemoglobins with Altered Synthesis or Function
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