Classical complement pathway activation is denoted by:

a. C2, C4 and C3 decreased.
b. C2 and C4 normal, C3 decreased.
c. C3 normal and C2, C4 decreased.
d. C2, C4, C3 all elevated.

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All of the following are part of innate immunity except:

a. Complement.
b. NK cells.
c. Macrophages.
d. T cells

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Prozone phenomenon is due to:

a. Antigen excess.
b. Antibody excess.
c. False +ve reaction.
d. False -ve reaction.

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What enhances multiplication of T cells in culture?

a. Phytohemagglutinin.
b. Chemotactic factor.
c. Leukotrienes.
d. Prostaglandins.

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All of the following are glycoproteins except:

a. Blood antigen.
b. Albumin.
c. Immunoglobulin.
d. hCG.

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All of the following are involved in antigen antibody reaction except:

a. Van der Waals forces.
b. Electrostatic bond.
c. Hydrogen bond.
d. Covalent bond.

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Interleukin 1 produces:

a. T-lymphocyte activation.
b. Delayed wound healing.
c.. Increased pain perception.
d. Decreased PMN release from marrow.

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The serum concentration of which of the following IgG subclasses is maximum?

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a. IgG1
b. IgG2
c. IgG3
d. IgG4

All of the following are found in Primary Sjogren syndrome except:

a. Lymphoma.
b. Connective Tissue disorder.
c. Xerostomia.
d. Xeropthalmia.

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Sicca syndrome is associated with all except:

a. Midline granuloma.
b. Chronic active hepatitis.
c. Rheumatoid arthritis.
d. Scleroderma.


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Indications for steroids in SLE are all except:

a. Myocarditis.
b. Endocarditis.
c. Thrombocytopenia.
d. Neuropsychiatric symptoms.


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In which of the following arthritis, erosions are not seen:

a. Rheumatoid Arthritis.
b. Psoriasis.
c. SLE.
d. Gout.



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Autoimmune destruction of platelets is seen in:

a. SLE.
b. Rheumatoid Arthritis.
c. Reiter disease.
d. Polyarteritis nodosa.



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Antibody found in myositis is

1. Anti Jo1
2. Anti scl 70
3. Anti Sm
4. Anti Ku
   
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Anticentromere antibodies are most commonly associated with:

a. Diffuse cutaneous systemic sclerosis.
b. Mixed CT disease.
c. CREST syndrome.
d. Polymyositis.

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All the following diseases are associated with HLA B 27 and uveitits, except:

a. Behcet's syndrome.
b. Psoriasis.
c. Ankylosing spondylitis.
d. Reiter's syndrome.




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Hemophilia with rheumatoid arthritis, analgesic of choice:

1. Ibuprofen.
2. Aspirin.
3. Acetaminophen.
4. Phenylbutazone.

The following are rheumatoid disease modifying drugs except:

1. Chloroquine.
2. Gold.
3. Penicillamine.
4. BAL.

Disease-modifying_antirheumatic_drug

A 45 year old coal mine worker presents with cutaneous nodules, joint pain and occasional cough with dyspnea. His chest radiograph shows multiple, small nodules in bilateral lung fields. Some of the nodules show cavitation and specks of calcification. Most likely these features are diagnostic of:

1. Sjogren's syndrome
2. Caplan's syndrome
3. Silicosis
4. Wegener's granulomatosis.

Type of anemia seen in Rheumatoid arthritis is :

a. Microcytic hypochromic

b. Macrocytic hypochromic

c. Normocytic hypochromic

d. Normocytic normochromic.