Table 99-3 Representative Abnormal Hemoglobins with Altered Synthesis or Function

 

Sickle or S
^6GluVal
African
Anemia, ischemic infarcts

C
^6GluLys
African
Mild anemia; interacts with HbS

E
^26GluLys
Southeast Asian
Microcytic anemia, splenomegaly, thalassemic phenotype

Köln
^98ValMet
Sporadic
Hemolytic anemia, Heinz bodies when splenectomized

Yakima
^99AspHis
Sporadic
Polycythemia

Kansas
^102AsnLys
Sporadic
Mild anemia

M. Iwata
^87HisTyr
Sporadic
Methemoglobinemia