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Table 105-3 WHO Classification of Lymphoid Malignancies



B Cell T Cell Hodgkin's Disease
Precursor B cell neoplasm
Precursor T cell neoplasm
Nodular lymphocyte-predominant Hodgkin's disease
Precursor B lymphoblastic leukemia/lymphoma (precursor B cell acute lymphoblastic leukemia) Precursor T lymphoblastic lymphoma/leukemia (precursor T cell acute lymphoblastic leukemia)
Mature (peripheral) B cell neoplasms Mature (peripheral) T cell neoplasms Classical Hodgkin's disease
B cell chronic lymphocytic leukemia/small lymphocytic lymphoma T cell prolymphocytic leukemia Nodular sclerosis Hodgkin's disease
B cell prolymphocytic leukemia T cell granular lymphocytic leukemia Lymphocyte-rich classic Hodgkin's disease
Lymphoplasmacytic lymphoma Aggressive NK cell leukemia Mixed-cellularity Hodgkin's disease
Splenic marginal zone B cell lymphoma (± villous lymphocytes) Adult T cell lymphoma/leukemia (HTLV-I+) Lymphocyte-depletion Hodgkin's disease
Hairy cell leukemia Extranodal NK/T cell lymphoma, nasal type
Plasma cell myeloma/plasmacytoma Enteropathy-type T cell lymphoma
Extranodal marginal zone B cell lymphoma of MALT type Hepatosplenic d T cell lymphoma
Mantle cell lymphoma Subcutaneous panniculitis-like T cell lymphoma
Follicular lymphoma Mycosis fungoides/Sézary syndrome
Nodal marginal zone B cell lymphoma (± monocytoid B cells) Anaplastic large cell lymphoma, primary cutaneous type
Diffuse large B cell lymphoma Peripheral T cell lymphoma, not otherwise specified (NOS)
Burkitt's lymphoma/Burkitt cell leukemia Angioimmunoblastic T cell lymphoma
Anaplastic large cell lymphoma, primary systemic type


Note: HTLV, human T cell lymphotropic virus; MALT, mucosa-associated lymphoid tissue; NK, natural killer; WHO, World Health Organization.
Malignancies in bold occur in at least 1% of patients.

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