Table 105-4 Infectious Agents Associated with the Development of Lymphoid Malignancies

Infectious Agent	Lymphoid Malignancy
Epstein-Barr virus	Burkitt's lymphoma Post–organ transplant lymphoma Primary CNS diffuse large B cell lymphoma Hodgkin's disease Extranodal NK/T cell lymphoma, nasal type
HTLV-I	Adult T cell leukemia/lymphoma
HIV	Diffuse large B cell lymphoma Burkitt's lymphoma
Hepatitis C virus	Lymphoplasmacytic lymphoma
Helicobacter pylori	Gastric MALT lymphoma
Human herpesvirus 8	Primary effusion lymphoma Multicentric Castleman's disease

MALT lymphomas of the skin may be related to Borrelia sp. infections, those of the eyes to Chlamydophila psittaci, and those of the small intestine to Campylobacter jejuni.

Infection with HIV predisposes to the development of aggressive, B cell non-Hodgkin's lymphoma. This may be through overexpression of interleukin 6 by infected macrophages