The production of armed effector T cells - Immunobiology - NCBI Bookshelf

The production of armed effector T cells - Immunobiology - NCBI Bookshelf

In the initial encounter of T cells with antigen-presenting cells, CD2 binding to LFA-3 on the antigen-presenting cell synergizes with LFA-1 binding to ICAM-1 and ICAM-2. One interaction that appears to be exclusive to the interaction of naive T cells with dendritic cells is that between ICAM-3 on the naive T cell and a recently identified molecule specific to dendritic cells and known as DC-SIGN. DC-SIGN is a C-type lectin that binds ICAM-3 with high affinity. LFA-1 is the α_L:β₂ integrin heterodimer CD11a:CD18. LFA-3 is also known as CD58, and ICAM-1, -2, and -3 are CD54, CD102, and CD50, respectively.