AIIMS NOV 2011- Direct repeats from ASN 2006

Ref: Review of AIIMS by Ashish - Amit.

PHYSIOLOGY


12. Adrenaline, noradernaline and dopamine act through:

a. Single pass receptor
b. Four pass receptor
c. Seven pass receptor
d. Ligand gated receptor


14. Mean arterial pressure is calculated as:

a. (SBP + 2DBP)/3
b. (DBP + 2SBP)/3
c. (SBP + 3DBP)/2
d. (DPB + 3SBP)/2


BIOCHEMISTRY

20. Same amino acid is coded by multiple codons due to following:

a. Degeneracy
b. Frame-shift mutation
c. Transcription
d. Mutation


23.  Anticoagulant used to estimate glucose from a sample sent from PHC is

a. EDTA
b. Calcium oxalate
c. Potassium oxalate + NaF
d. Sodium citrate


25. The 40 nm gap between the tropocollagen molecule in collagen, which serve as the site of bone formation is occupied by which of the following:

a. Carbohydrate
b. Ligand moeity
c. Ca++
d. Fe ++

COMMUNITY MEDICINE

39. You have diagnosed a patient clinically as having SLE and ordered 6 tests. Out of which 4 tests have come positive and 2 are negative. To determine the probability of SLE at this point, you need to know:

a. Prior probability of SLE; sensitivity and specificity of each test.
b. Incidence of SLE and predictive value of each test.
c. Incidence and prevalence of SLE.
d. Relative risk of SLE in this patient.


41. Direct standardization is used to compare the mortality rates between two countries. This is done because of the difference in:

a. Causes of death.
b. Denominators
c. Age distributions
d. Numerators.


45. Using a new technique, Hb was estimated in a blood sample.  The test was repeated 10 times.  The reports were :  9.5, 9.2, 9.4, 9.6, 9.7, 9.9, 10.2, 10.3, 10.5, 12.1. Accurate value of Hb was estimated by standard tests to be 10.2. The new technique has:

a. High validity and high reliability
b. Low validity and low reliability
c. High validity and low relibility
d. Low validity and high reliability.


46. In a study in UK, an association was found between sale of antiarrhytmic drug and an increase in deaths due to asthma. This is an example of

a. Ecological study
b. Cohort study
c. Case reference study
d. Experimental study.


49. Socialization of medicine leads to all except:

a. Ensures complete utilization of services by all people.
b. Free medical care supported by state.
c. Eliminates the competition among physicians in search of clients.
d. Ensures social equity, universal coverage of health services.


56. Which epidemiologicla study gives the most accurate result:

a. Meta analysis.
b. Cross-sectional study.
c. Randomized control trial with double blind.
d. Cohort study.


PHARMACOLOGY

72. The following drug is not useful for MRSA.

a. Cefaclor
b. Cotrimoxazole
c. Ciprofloxacin
d. Vancomycin


MICROBIOLOGY


74. An elderly male presented with fever, chest pain and dry coug.  Sputum cultured on charcoal yeast medium.  The organism is :

a. H.influenza
b. Moraxella catarrhalis
c. Legionella
d. Burkholderia cepacia


76. A young male presented with urethral discharge.  On urine examination, pus cells were found but no organisms. Which method would be the best for culture?

a. Mc coy cell line
b. Thayer Martin medium
c. LJ medium
d. Levinthal medium


80. With reference to Bacteroides fragilis, the following statements are true except:

a. B. fragilis is the same frequent anaerobe isolated from clinical samples.
b. B. fragilis is not uniformly sensitive to metronidazole.
c. The lipopolysachharide formed by B. fragilis is structurally and functionally different from the conventional endotoxin.
d. Shock and DIC are common in Bacteroides bacteremia.


81. A child had pustular lesion on leg. On gram staining, gram positive coccin are seen . To establish the diagnosis of Group A streptococcal erythroderma, the test used is :

a. Bile solubility test
b. Catalase test
c. Optochin sensitivity
d. Bacitracin sensitivity


82. A patient admitted to an ICU is on central venous line for last one week.  He is on ceftazidime and amikacin.  After 7 days of antibiotics, he develops a spike of fever and his blood culture is positive fro gram positive cocci in chains, which are catalase negative.  Following this, vancomycin was started but the culture remained positive for the same organism, even after 2 weeks of therapy.  The most likely organism causing infection is:

a. Staphylococcus aureus
b. Viridans streptococci
c. Enterococcus faecalis
d. Coagulase negative staphylococci.


PATHOLOGY:


93. In acute inflammation due to the contraction of endothelial cell cytoskeleton, whicn of the following results:

a. Delayed transient increase in permeability
b. Early transient increase
c. Delayed permanent increase
d. Early permanent increase


95. The most common gene defect in idiopathic steroid resistant nephrotic syndrome:

a. ACE
b. NPHS 2
c. HOX 11
d. PAX


MEDICINE


98. Reflux disease, which cause of proteinuria is nephrotic range?

a. Membranous glomerulonephritis
b. Focal segmental glomerulosclerosis
c. Nodular glomerulosclerosis
d. Crescenteric glomerulonephritis.


99. Which deleterious effect is least likely to occur in hypothermia?

a. Cardiac arrhythmia
b. Decreased peripheral resistance
c. Reversible coagulation
d. Renal failure.

104. Treatment for multiple sclerosis:

a. Interferon alpha
b. Interferon beta
c. Infliximab
d. Interferon gamma.


108. Which of the following is not a limb girdle dystrophy?

a. Sarcoglycan dystrophy
b. Dystrophin dystrophy
c. Dysferin dystrophy
d. Calpain dystrophy.


109. Which of the following is the most specific test for Rheumatoid arthritis?

a. Anti-ccp antibody
b. Anti Igm antibody
c. Anti IgA antibody
d. Anti IgG antibody


112. Which of the following exclusively involve neurons?

a. Spinocerebellar ataxia
b. Supranuclear palsy
c. Corticobasilar degeneration
d. Multiple system atrophy.


114. A young male patient presents with LDL 600 mg/dl, triglycerides 160 mg/dl.  What would be the most likely finding on physical examination?

a. Tendon xanthoma.
b. Lipemia retinalis
c. Eruptive tuberous xanthoma
d. Xanthelasma.


119. HAM test is done for:

a. GPI anchor protein
b. Complement defect
c. Spectrin defect
d. Mannose binding protein.


120. 16 year old with primary amenorrhea attends OPD. She has normal sexual development and normal breast but with absent pubic and axillary hair.  Examination shows b/l inguinal hernias.  USG shows absent uterus and blind vagina.  Diagnosis will be:

a. Turner syndrome
b. Mullerian agenesis
c. STAR syndrome
d. Androgen insensitivity syndrome.


PEDIATRICS


121. A newborn presents with congestive heart failure, on examination has bulging anterior fontanellae with a bruit on auscultation.  Trans fontanella USG shows a hypoechoic midline mass with dilated lateral ventricles.  Most likely diagnosis is:

a. Medulloblastoma.
b. Encephalocele
c. Vein of Galen malformation
d. Arachnoid cyst.


123. All the following can occur in a neonate for heat production except:

a. Shivering
b. Breakdown of brown fat with adrenaline secretion
c. Universal flexion like a fetus
d. Cutaneous vasoconstriction.


127. The most important fatty acid present in breast milk for growth is:

a. Docosahexaenoic acid
b. Palmitic acid
c. Linoleic acid.
d. Linolenic acid.


SURGERY:


144. Which fruit juice helps in preventing UTI:

a. Grape
b. Raspberry
c. Cranberry
d. Orange


149. Which is not elevated in a child presenting with icterus, pruritus and clay coloured stools.

a. Gamma glutamyl transpeptidase
b. Alkaline phosphatase
c. 5- nucleotidase
d. Glutamate dehydrogenase.


151. A 45-yr old female complaints of progressive lower limb weakness, spasticity, urinary hesitancy.  MRI shows intradural enhancing mass lesion.  Most likely diagnosis is:

a. Dermoid cyst
b. Intradural lipoma
c. Neuroepithelial cyst
d. Meningioma.


OBSTETRICS AND GYNECOLOGY


162. Which drug is given to prevent HIV transmission from mother to child?

a. Nevirapine
b. Lamivudine
c. Stavudine
d. Abacavir


163. After coming head of breech will have difficulty in delivery in all the following conditions except:

a. Hydrocephalus
b. Placenta previa
c. Incomplete dilation of cervix
d. Extension of head.


166. Lady with infertility with b/l tubal block at cornua.  Best method of managment:

a. Laparoscopy and Hysteroscopy
b. Hydrotubation
c. IVF
d. Tuboplasty


172. Which of the following is the least likely physiological change in pregnancy?

a. Increase in intravascular volume
b. Increase in cardiac output
c. Increase in stroke volume
d. Increase in peripheral vascular resistance.


174. Premature baby of 34 weeks was delivered. Baby had bullous lesion on the body.  X-ray shows periostitis.  What is the next investigation?

a. VDRL for mother and baby
b. ELISA for HIV
c. PCR for TB
d. Hepatitis surface antigen for mother.


OPHTHALMOLOGY


180.  Oculomotor nerve palsy causes all except:

a. Miosis
b. Ptosis
c. Outward eye deviation
d. Diplopia.


SKIN


187. A 3 year old child has eczematous dermatitis on extensor surfaces. His mother has a history of bronchial asthma.  Diagnosis should be:

a. Atopic dermatitis
b. Contact dermatitis
c. Seborrheic dermatitis
d. Infantile eczematous dermatitis


ANAESTHESIA


188. Which of the following is not true of Xenon anaesthesia?

a. Non explosive
b. Mnimal CVS side effect
c. Slow induction and recovery
d. Low blood gas solubility


189. Which of the following anaesthesia will produce decreased EEG activities?

a. Hypothermia
b. Early hypoxia
c. Ketamine
d. N2O