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20110512

The primary defect which leads to sickle cell anemia is:


  1. An abnormality inn porphyrin part of hemoglobin.
  2. Replacement of glutamate by valine in beta chain of HbA.
  3. A nonsense mutation in the beta chain of HbA.
  4. Substitution of valine by glutamate in the alpha chain of HbA.
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