The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, NCX, or exchange protein) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). The NCX removes a single calcium ion in exchange for the import of three sodium ions.
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20110728
Sodium-calcium exchanger
Sodium-calcium exchanger - Wikipedia, the free encyclopedia: "The sodium-calcium exchanger (often denoted Na+/Ca2+ exchanger, NCX, or exchange protein) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). The NCX removes a single calcium ion in exchange for the import of three sodium ions."
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20110727
Pharmacology Memory Cards:
PharMnemonics: 1> Linking a drug name (Pilocarpine) to its action (Pupil constriction): PILOCARPINE: A PILE of CAR-delivered PINEs is used for the pupil constri(u)ction project (illustruated with a figure). 2> Linking a drug class stem (-pril) to its action (Inhibition of an enzyme called ACE): PRIL: PERIL is gone with E (Enzyme ACE). By knocking out the E, the PERIL is replaced with a -PRIL pill and the capital PERIL of hypertension and CHF can be diminished by captoPRIL (illustruated with a figure). 3> Linking a drug name (Sumatriptan) to its use (treatment of Migraine): SUMATRIPTAN: If you have migraine in the SUMMER, simply take A TRIP for TAN. Just relax (illustruated with a figure). 4> Linking a drug name (PHENyTOIN) to its side effects: Peripheral neuropathy. Hyperplasia of gingiva, Hirsutism and coarse facial features. Hypersensitivity: skin rash and even Stevens-Johnson syndrome. Enlarged lymph nodes (lymphadenopathy). Nystagmus, diplopia and sedation. Teratogenicity ("Fetal hydantoin syndrome"). Osteomalacia (due to decreased Vitamin D), megalOblastic anemia (due to deceased folate levels). Inhibition of ADH and insulin secretion. Nausea and vomiting 5> Linking a drug class (SSRIs) to its side effects: Sick stomach, leading to anorexia, nausea, etc. Sexual dysfunction. Restless: agitation, anxiety and tremor. Insomnia. Serotonin syndrome. Caused by concurrent use of MAOIs 6> Linking a disease name (DIABETES mellitus) to its drugs or drug classes: DDP-4 inhibitors (Sitagliptin) Insulins. Amylin analog (Pramlinitide). Acarbose (Alpha-glucosidase inhibitors). Biguanides (Metformin). Exenatide (GLP-1 agonists). Thiazolidinediones (PPARr agonists). Excercise and weight control (Essential for the control of type II DM). Sulfonylureas(Insulin secretagogues). 7> Dr. Bright's hint: Intern: Doc, of drugs used in Parkinson's disease, what drugs are better for relieving Bradykinesia? Dr: Bromocriptine and related DA agonists. Intern: Then, what drugs are better for attenuating Tremor? Dr: Trihexyphenidyl and related antimuscarinic agents. 8> Dr. Bright's hint: Intern: Doc, why can lithium cause nephrogenic diabetes insipidus? Dr: As you can see in the figure on the left, this is because the lithium battery overcharges the water pump
20110714
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