- HbS differs from HbA by the substitution of Val for Glu in position 6 of the beta chain.
- One altered peptide of HbS migrates faster towards the cathode than the corresponding peptide of HbA.
- Binding of HbS to the deoxygenated HbA can extend the polymer and cause sickling of the red blood cells.
- Lowering the concentration of deoxygenated HbS can prevent sickling.
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3. Binding of HbS to the deoxygenated HbA can extend the polymer and cause sickling of the RBC.
ReplyDeleteHbA, HbC and HbF afford protective affect from sickling.